The rotational behavior model: asymmetry in the effects of unilateral 6-OHDA lesions of the substantia nigra in rats.
نویسندگان
چکیده
A basic assumption of the 'rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine (DA) system. However, we report here that if the normally 'dominant ' striatum is partially depleted of DA the majority of rats turn contraversive when given AMPH, i.e. in the opposite direction predicted by the model.
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ورودعنوان ژورنال:
- Brain research
دوره 264 1 شماره
صفحات -
تاریخ انتشار 1983